Team 1 Publications

Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Chen, Baohui; Gilbert, Luke A; Cimini, Beth A; Schnitzbauer, Joerg; Zhang, Wei; Li, Gene-Wei; Park, Jason; Blackburn, Elizabeth H; Weissman, Jonathan S; Qi, Lei S; Huang, Bo, Cell, 7,155:1479-91 (2013).

Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. Hangauer, Matthew J; Vaughn, Ian W; McManus, Michael T, PLoS Genet, 6,9:e1003569 (2013).

A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Bassik, Michael C; Kampmann, Martin; Lebbink, Robert Jan; Wang, Shuyi; Hein, Marco Y; Poser, Ina; Weibezahn, Jimena; Horlbeck, Max A; Chen, Siyuan; Mann, Matthias; Hyman, Anthony A; Leproust, Emily M; McManus, Michael T; Weissman, Jonathan S, Cell, 4,152:909-22 (2013).

Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells. Kampmann, Martin; Bassik, Michael C; Weissman, Jonathan S, Proc Natl Acad Sci U S A, 25,110:E2317-26 (2013).

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Gilbert, Luke A; Larson, Matthew H; Morsut, Leonardo; Liu, Zairan; Brar, Gloria A; Torres, Sandra E; Stern-Ginossar, Noam; Brandman, Onn; Whitehead, Evan H; Doudna, Jennifer A; Lim, Wendell A; Weissman, Jonathan S; Qi, Lei S, Cell, 2,154:442-51 (2013).

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Qi, Lei S; Larson, Matthew H; Gilbert, Luke A; Doudna, Jennifer A; Weissman, Jonathan S; Arkin, Adam P; Lim, Wendell A, Cell, 5,152:1173-83 (2013).

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation. van de Weijer, Michael L; Bassik, Michael C; Luteijn, Rutger D; Voorburg, Cornelia M; Lohuis, Mirjam A M; Kremmer, Elisabeth; Hoeben, Rob C; LeProust, Emily M; Chen, Siyuan; Hoelen, Hanneke; Ressing, Maaike E; Patena, Weronika; Weissman, Jonathan S; McManus, Michael T; Wiertz, Emmanuel J H J; Lebbink, Robert Jan, Nat Commun, 5:3832 (2014).

A protein-tagging system for signal amplification in gene expression and fluorescence imaging. Tanenbaum, Marvin E; Gilbert, Luke A; Qi, Lei S; Weissman, Jonathan S; Vale, Ronald D, Cell, 3,159:635-46 (2014).

Systematic identification of barriers to human iPSC generation. Qin, Han; Diaz, Aaron; Blouin, Laure; Lebbink, Robert Jan; Patena, Weronika; Tanbun, Priscilia; LeProust, Emily M; McManus, Michael T; Song, Jun S; Ramalho-Santos, Miguel, Cell, 2,158:449-61 (2014).

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.Gilbert, Luke A; Horlbeck, Max A; Adamson, Britt; Villalta, Jacqueline E; Chen, Yuwen; Whitehead, Evan H; Guimaraes, Carla; Panning, Barbara; Ploegh, Hidde L; Bassik, Michael C; Qi, Lei S; Kampmann, Martin; Weissman, Jonathan S, Cell, 3,159:647-61 (2014).

Development of siRNA payloads to target KRAS-mutant cancer. Yuan, Tina L; Fellmann, Christof; Lee, Chih-Shia; Ritchie, Cayde D; Thapar, Vishal; Lee, Liam C; Hsu, Dennis J; Grace, Danielle; Carver, Joseph O; Zuber, Johannes; Luo, Ji; McCormick, Frank; Lowe, Scott W, Cancer Discov, 10,4:1182-97 (2014).

Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors. Sos, Martin L; Levin, Rebecca S; Gordan, John D; Oses-Prieto, Juan A; Webber, James T; Salt, Megan; Hann, Byron; Burlingame, Alma L; McCormick, Frank; Bandyopadhyay, Sourav; Shokat, Kevan M, Cell Rep, 4,8:1037-48 (2014).

Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps. Kampmann, Martin; Bassik, Michael C; Weissman, Jonathan S, Nat Protoc, 8,9:1825-47 (2014).

Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR.Boettcher, Michael; McManus, Michael T, Mol Cell, 4,58:575-85 (2015).

Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map. Martins, Maria M; Zhou, Alicia Y; Corella, Alexandra; Horiuchi, Dai; Yau, Christina; Rakshandehroo, Taha; Gordan, John D; Levin, Rebecca S; Johnson, Jeff; Jascur, John; Shales, Mike; Sorrentino, Antonio; Cheah, Jaime; Clemons, Paul A; Shamji, Alykhan F; Schreiber, Stuart L; Krogan, Nevan J; Shokat, Kevan M; McCormick, Frank; Goga, Andrei; Bandyopadhyay, Sourav, Cancer Discov, 2,5:154-67 (2015).

Next-generation libraries for robust RNA interference-based genome-wide screens. Kampmann, Martin; Horlbeck, Max A; Chen, Yuwen; Tsai, Jordan C; Bassik, Michael C; Gilbert, Luke A; Villalta, Jacqueline E; Kwon, S Chul; Chang, Hyeshik; Kim, V Narry; Weissman, Jonathan S, Proc Natl Acad Sci U S A, 26,112:E3384-91 (2015).

KRAS as a Therapeutic Target. McCormick, Frank, Clin Cancer Res, 8,21:1797-801 (2015).

Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. Acosta-Alvear, Diego; Cho, Min Y; Wild, Thomas; Buchholz, Tonia J; Lerner, Alana G; Simakova, Olga; Hahn, Jamie; Korde, Neha; Landgren, Ola; Maric, Irina; Choudhary, Chunaram; Walter, Peter; Weissman, Jonathan S; Kampmann, Martin, Elife, 4:e08153 (2015).

Tetsu, Osamu; Hangauer, Matthew J; Phuchareon, Janyaporn; Eisele, David W; McCormick, Frank, Chemotherapy, 5,61:223-35 (2016).

Drug Resistance to EGFR Inhibitors in Lung Cancer. Tetsu, Osamu; Hangauer, Matthew J; Phuchareon, Janyaporn; Eisele, David W; McCormick, Frank, Chemotherapy. 61 (5) :223-35 (2016).

Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance.. Gerhard DS, Clemons PA, Shamji AF, Hon C, Wagner BK, Schreiber SL, Krasnitz A, Sordella R, Sander C, Lowe SW, Powers S, Smith K, Aburi M, Iavarone A, Lasorella A, Silva J, Stockwell BR, Califano A, Boehm JS, Vazquez F, Weir BA, Hahn WC, Khuri FR, Moreno CS, Johns M, Fu H, Nikolova O, Mendez E, Gadi VK, Margolin AA, Grandori C, Kemp CJ, Warren EH, Riddell SR, McIntosh MW, Gevaert O, Kuo CJ, Ji HP, Dhruv H, Finlay D, Kiefer J, Kim S, Vuori K, Berens ME, Hangauer M, Boettcher M, Weissman JS, Bivona TG, Bandyopadhyay S, McManus MT, McCormick F, Aksoy O, Simonds EF, Zheng T, Chen J, An Z, Balmain A, Weiss WA, Chen K, Liang H, Scott KL, Mills GB, Posner BA, MacMillan J, Minna J, White M, Roth MG, Jagu S, Mazerik J. Mol Cancer Res. [Epub ahead of print] (2016).