Team 2 Publications

Generating trunk neural crest from human pluripotent stem cells. Huang, Miller; Miller, Matthew L; McHenry, Lauren K; Zheng, Tina; Zhen, Qiqi; Ilkhanizadeh, Shirin; Conklin, Bruce R; Bronner, Marianne E; Weiss, William A. Scientific reports. 6 :19727 (2016)

Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers. McCreery, Melissa Q; Halliwill, Kyle D; Chin, Douglas; Delrosario, Reyno; Hirst, Gillian; Vuong, Peter; Jen, Kuang-Yu; Hewinson, James; Adams, David J; Balmain, Allan Nature medicine. 2015 Dec; 21 (12) :15

EGFR blockade prevents glioma escape from BRAFV600E targeted therapy. Yao, Tsun-Wen; Zhang, Jie; Prados, Michael; Weiss, William A; James, C David; Nicolaides, Theodore. Oncotarget. 2015 Sep 8; 6 (26) :21993 (2015).

Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma. Li, Nan; Maly, Dustin J; Chanthery, Yvan H; Sirkis, Daniel W; Nakamura, Jean L; Berger, Mitchel S; James, C David; Shokat, Kevan M; Weiss, William A; Persson, Anders I, Molecular cancer therapeutics. 14 (2) :419-28 (2015).

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer.  Westcott, Peter M K; Halliwill, Kyle D; To, Minh D; Rashid, Mamunur; Rust, Alistair G; Keane, Thomas M; Delrosario, Reyno; Jen, Kuang-Yu; Gurley, Kay E; Kemp, Christopher J; Fredlund, Erik; Quigley, David A; Adams, David J; Balmain, Allan. Nature. 517 (7535) :489-92 (2015).

Alternative splicing in cancer: implications for biology and therapy. Chen, J; Weiss, W A. Oncogene. 34 (1) :1-14 (2015).

The genetics of splicing in neuroblastoma. Chen, Justin; Hackett, Christopher S; Zhang, Shile; Song, Young K; Bell, Robert J A; Molinaro, Annette M; Quigley, David A; Balmain, Allan; Song, Jun S; Costello, Joseph F; Gustafson, W Clay; Van Dyke, Terry; Kwok, Pui-Yan; Khan, Javed; Weiss, William A. Cancer discovery. 5 (4) :380-95 (2015). 

Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma. Hackett, Christopher S; Quigley, David A; Wong, Robyn A; Chen, Justin; Cheng, Christine; Song, Young K; Wei, Jun S; Pawlikowska, Ludmila; Bao, Yun; Goldenberg, David D; Nguyen, Kim; Gustafson, W Clay; Rallapalli, Sundari K; Cho, Yoon-Jae; Cook, James M; Kozlov, Serguei; Mao, Jian-Hua; Van Dyke, Terry; Kwok, Pui-Yan; Khan, Javed; Balmain, Allan; Fan, QiWen; Weiss, William A. Cell reports. 9 (3) :1034-46 (2014). 

Drugging MYCN through an allosteric transition in Aurora kinase A. Gustafson, William Clay; Meyerowitz, Justin Gabriel; Nekritz, Erin A; Chen, Justin; Benes, Cyril; Charron, Elise; Simonds, Erin F; Seeger, Robert; Matthay, Katherine K; Hertz, Nicholas T; Eilers, Martin; Shokat, Kevan M; Weiss, William A. Cancer cell. 26 (3) :414-27 (2014).  

When deletions gain functions: commandeering epigenetic mechanisms. Chen, Justin; Weiss, William A. Cancer cell. 26 (2) :160-1 (2014).        

Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Tang, Yujie; Gholamin, Sharareh; Schubert, Simone; Willardson, Minde I; Lee, Alex; Bandopadhayay, Pratiti; Bergthold, Guillame; Masoud, Sabran; Nguyen, Brian; Vue, Nujsaubnusi; Balansay, Brianna; Yu, Furong; Oh, Sekyung; Woo, Pamelyn; Chen, Spenser; Ponnuswami, Anitha; Monje, Michelle; Atwood, Scott X; Whitson, Ramon J; Mitra, Siddhartha; Cheshier, Samuel H; Qi, Jun; Beroukhim, Rameen; Tang, Jean Y; Wechsler-Reya, Rob; Oro, Anthony E; Link, Brian A; Bradner, James E; Cho, Yoon-Jae. Nature medicine. 20 (7) :732-40 (2014).        

Could α5-GABA-A receptor activation be used as a target for managing medulloblastomas? Sengupta, Soma; Weeraratne, Shyamal D; Cho, Yoon-Jae; Pomeroy, Scott L. CNS oncology. 3 (4) :245-7 (2014).         

Identification of Hipk2 as an essential regulator of white fat development. Sjölund, Jonas; Pelorosso, Facundo G; Quigley, David A; DelRosario, Reyno; Balmain, Allan. Proceedings of the National Academy of Sciences of the United States of America. 111 (20) :7373-8 (2014).     

BET bromodomain inhibition of MYC-amplified medulloblastoma. Bandopadhayay, Pratiti; Bergthold, Guillaume; Nguyen, Brian; Schubert, Simone; Gholamin, Sharareh; Tang, Yujie; Bolin, Sara; Schumacher, Steven E; Zeid, Rhamy; Masoud, Sabran; Yu, Furong; Vue, Nujsaubnusi; Gibson, William J; Paolella, Brenton R; Mitra, Siddhartha S; Cheshier, Samuel H; Qi, Jun; Liu, Kun-Wei; Wechsler-Reya, Robert; Weiss, William A; Swartling, Fredrik J; Kieran, Mark W; Bradner, James E; Beroukhim, Rameen; Cho, Yoon-Jae. Clinical cancer research : an official journal of the American Association for Cancer Research. 20 (4) :912-25 (2014).      

 *5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth. Sengupta, Soma; Weeraratne, Shyamal Dilhan; Sun, Hongyu; Phallen, Jillian; Rallapalli, Sundari K; Teider, Natalia; Kosaras, Bela; Amani, Vladimir; Pierre-Francois, Jessica; Tang, Yujie; Nguyen, Brian; Yu, Furong; Schubert, Simone; Balansay, Brianna; Mathios, Dimitris; Lechpammer, Mirna; Archer, Tenley C; Tran, Phuoc; Reimer, Richard J; Cook, James M; Lim, Michael; Jensen, Frances E; Pomeroy, Scott L; Cho, Yoon-Jae. Acta neuropathologica. 127 (4) :593-603 (2014).   

The prenatal origins of cancer. Marshall, Glenn M; Carter, Daniel R; Cheung, Belamy B; Liu, Tao; Mateos, Marion K; Meyerowitz, Justin G; Weiss, William A. Nature reviews. Cancer. (4) :277-89 (2014).

Glial progenitors as targets for transformation in glioma. Ilkanizadeh, Shirin; Lau, Jasmine; Huang, Miller; Foster, Daniel J; Wong, Robyn; Frantz, Aaron; Wang, Susan; Weiss, William A; Persson, Anders I. Advances in cancer research. 121 :1-65 (2014).       

Milestones in skin carcinogenesis: the biology of multistage carcinogenesis. Balmain, Allan; Yuspa, Stuart H. The Journal of investigative dermatology. 134 (e1) :E2-7 (2014).       

It takes two to tango: Dual inhibition of PI3K and MAPK in rhabdomyosarcoma. Jahangiri, Arman; Weiss, William A. Clinical cancer research : an official journal of the American Association for Cancer Research. 19 (21) :5811-3 (2013).           

EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Fan, Qi-Wen; Cheng, Christine K; Gustafson, W Clay; Charron, Elizabeth; Zipper, Petra; Wong, Robyn A; Chen, Justin; Lau, Jasmine; Knobbe-Thomsen, Christiane; Weller, Michael; Jura, Natalia; Reifenberger, Guido; Shokat, Kevan M; Weiss, William A. Cancer cell. 24 (4) :438-49 (2013).       

Neuroblastoma and MYCN. Cold Spring Harbor perspectives in medicine. Huang, M; Weiss WA. 3 (10) :a014415 (2013).