Unlocking Cancer’s Secrets, Accelerating Therapies

At the UCSF CTD² Center, we are pioneering new ways to understand, decode, and disrupt the molecular circuits that drive cancer. As part of the National Cancer Institute’s Cancer Target Discovery and Development (CTD²) Network, our mission is to bridge the gap between genomic discovery and therapeutic impact.

Harnessing the power of functional genomics, single-cell analysis, and synthetic biology, we explore how genetic alterations rewire cell states and immune responses—creating both vulnerabilities and opportunities for intervention. From advanced CRISPR screening to cell-based imaging platforms, we work at the interface of technology development, tumor biology, and immune engineering to discover targets that matter.

Our collaborative ecosystem spans UCSF labs and national partners, integrating computational and experimental strategies to illuminate novel cancer dependencies—and ultimately translate these insights into new diagnostics and therapeutics.

Join us as we chart new paths from discovery to cure.